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Antigenic Specificity | TRAF3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Tumor necrosis factor (TNF) receptor associated factors (TRAFs) are the major signal transducers for the TNF receptor superfamily and the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily. TRAF3 was first identified by its interaction with CD40 and the Epstein-Barr virus transforming protein LMP1. Several TRAF3 mRNA splice variants exist and some of these can activate the transcription factor NF-kB. Besides CD40, TRAF3 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF2 and the apoptosis inhibitors cIAP1 and Smac. It has been suggested that TRAF3 induces mitochondria-mediated apoptosis upon binding of the TNF family cytokine LIGHT by LTbetaR. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 16 amino acid peptide from near the carboxy terminus of human TRAF3. |
Other Names | [TNF receptor-associated factor 3, CD40 binding protein, LMP1 associated protein 1, CD40BP, LAP] |
Gene, Accession # | [TRAF3], Gene ID: 7187, NCBI: NP_663777 |
Catalog # | MBS9411655 |
Price | $320 |
Order / More Info | TRAF3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |