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Antigenic Specificity | PLK3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. In |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 487-646 of human PLK3 (NP 004064.2). |
Other Names | [CNK; FNK; PRK; PLK-3] |
Gene, Accession # | [PLK3], Gene ID: 1263, NCBI: NP_004064.2, UniProt: Q9H4B4 |
Catalog # | MBS8547547 |
Price | $280 |
Order / More Info | PLK3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |