Edit |   |
---|---|
Antigenic Specificity | Human Tyrosine-protein kinase Blk |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G |
Immunogen | Immunogen: Recombinant human Tyrosine-protein kinase Blk protein (1-280aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-329 / sc-938 |
Other Names | [B lymphocyte kinase; p55-Blk; BLK], [BLK; BLK; MODY11] |
Gene, Accession # | [BLK], Gene ID: 640, NCBI: NP_001706.2, UniProt: P51451 |
Catalog # | MBS1494002 |
Price | $120, $160 |
Order / More Info | Human Tyrosine-protein kinase Blk Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |