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Antigenic Specificity | MARK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total MARK protein. Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).Lizcano J.M., EMBO J. 23:833-843 |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human MARK. |
Other Names | [EC 2.7.11.1; MAP/microtubule affinity-regulating kinase 1; MARK] |
Gene, Accession # | [MARK], Gene ID: 4139, NCBI: NP_001273057.1, UniProt: Q9P0L2 |
Catalog # | MBS9402365 |
Price | $200, $255 |
Order / More Info | MARK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |