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Antigenic Specificity | COPS2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total COPS2 polyclonal antibody. Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases.CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Invo |
Immunogen | Immunogen: Recombinant Human COP9 signalosome complex subunit 2 protein (1-310aa) |
Other Names | [SGN2; Signalosome subunit 2; Alien homolog; JAB1-containing signalosome subunit 2; Thyroid receptor-interacting protein 15; TR-interacting protein 15; TRIP-15; COPS2; CSN2; TRIP15] |
Gene, Accession # | [COPS2], Gene ID: 9318, NCBI: NP_001137359.1, UniProt: P61201 |
Catalog # | MBS9416057 |
Price | $320 |
Order / More Info | COPS2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |