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Antigenic Specificity | CARD16 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 2mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total CARD16 protein. Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. |
Immunogen | Immunogen: Synthetic peptide corresponding to residues near the N terminal of human CARD16 Immunogen Type: Peptide |
Other Names | [COP; COP1; PSEUDO-ICE] |
Gene, Accession # | [CARD16], Gene ID: 114769, NCBI: NP_001017534, UniProt: Q5EG05 |
Catalog # | MBS9429551 |
Price | $255 |
Order / More Info | CARD16 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |