POLB Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | POLB |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Description: Rabbit IgG polyclonal antibody for DNA polymerase beta(POLB) detection. Tested with WB in Human. Background: Polymerase (DNA directed), beta, also known as POLB, is an enzyme that, in humans, is encoded by the POLB gene. It is localized on 8p11.2. The protein encoded by this gene is a DNA polymerase involved in base excision and repair, also called gap-filling DNA synthesis. It is found that a truncated POLB is expressed in primary colorectal tumors and inhibits the normal repair function of wildtype POLB. The encoded protein, acting as a monomer, is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage. Several transcript variants of this gene exist, but the full-length nature of only one has been |
| Immunogen | Immunogen: E Coli-derived human POLB recombinant protein (Position: L122-E335). Human POLB shares 95.3% and 94.9% amino acid (aa) sequence identity with mouse and rat POLB, respectively. Ig Type: Rabbit IgG |
| Other Names | [DNA polymerase beta; DNA directed DNA polymerase beta; DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DPOLB_HUMAN; MGC125976; Pol B; Pol beta; POLB; Polymerase (DNA directed) beta; polymerase (DNA directed), beta], [POLB; POLB] |
| Gene, Accession # | [POLB], Gene ID: 5423, NCBI: NP_002681.1, UniProt: P06746 |
| Catalog # | MBS178313 |
| Price | $280 |
| Order / More Info | POLB Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Entrez Gene: POLB polymerase (DNA directed), beta. 2. Bhattacharyya, N., Banerjee, S. A variant of DNA polymerase beta acts as a dominant negative mutant. Proc. Nat. Acad. Sci. 94: 10324-10329, 1997. 3. El-Andaloussi, N., Valovka, T., Toueille, M., Steinacher, R., Focke, F., Gehrig, P., Covic, M., Hassa, P. O., Schar, P., Hubscher, U., Hottiger, M. O. Arginine methylation regulates DNA polymerase beta. Molec. Cell 22: 51-62, 2006. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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