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Antigenic Specificity | NOTUM |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | In Drosophila, the notum gene is regulated by the Wingless pathway and encodes a secreted hydrolase that modifies heparan sulfate proteoglycans. The mammalian homolog has been shown to be able to cleave glypicans and can release GPI-anchored proteins from the mammalian cell surface. Like the Drosophilia NOTUM, the mammalian protein can act as a negative regulator of the Wnt signaling pathway. NOTUM is expressed at a low level in most mammalian tissues, although it is overexpressed in a subset of human hepatocellular carcinomas. Its transcription is regulated by beta-catenin/TCF and is a target of the Wnt signaling pathway, forming a negative feedback loop that regulates the expression and activity of the Wnt pathway. |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 19 amino acid peptide near the amino terminus of human NOTUM. |
Other Names | [NOTUM pectinacetylesterase homolog] |
Gene, Accession # | [NOTUM], Gene ID: 147111, NCBI: NP_848588 |
Catalog # | MBS9413969 |
Price | $320 |
Order / More Info | NOTUM Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |