MuSK (Phospho-Tyr755) Antibody from MYBIOSOURCE INC.
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|---|---|
| Antigenic Specificity | MuSK (Phospho-Tyr755) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous levels of MuSK only when phosphorylated at tyrosine 755. Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. Valenzuela D.M., Neuron 15:5 |
| Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of tyrosine 755(A-D-Y(p)-Y-K) derived from Human MuSK. |
| Other Names | [MUSK; Muscle; skeletal] |
| Gene, Accession # | [MuSK], Gene ID: 4593, NCBI: NP_001159752.1, UniProt: O15146 |
| Catalog # | MBS9412317 |
| Price | $200, $255 |
| Order / More Info | MuSK (Phospho-Tyr755) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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