CDC25C Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-CDC25C antibody, protein, ELISA kits.
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| Antigenic Specificity | CDC25C |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis (1). cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1, while phosphorylation at this site is DNA damage-dependent at the G2/M checkpoint (2). When phosphorylated at Ser216, cdc25C binds to members of the 14-3-3 family of proteins, sequestering cdc25C in the cytoplasm and thereby preventing premature mitosis (3). The checkpoint kinases Chk1 and Chk2 phosphorylate cdc25C at Ser216 in response to DNA damage (4, 5). |
| Immunogen | Immunogen: Recombinant protein of human CDC25C Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [CDC25; PPP1R60] |
| Gene, Accession # | [CDC25C], Gene ID: 995, NCBI: NP_001274511.1, UniProt: P30307 |
| Catalog # | MBS8501977 |
| Price | $310 |
| Order / More Info | CDC25C Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Jessus, C. and Ozon, R. (1995) Prog. Cell Cycle Res. 1, 215-228. 2. Peng, C.Y. et al. (1997) Science 277, 1501-1505. 3. Kumagai, A. and Dunphy, W.G. (1999) Genes Dev. 13, 1067-1072. 4. Blasina, A. et al. (1999) Curr. Biol. 9, 1-10. 5. Furnari, B. et al. (1999) Mol. Biol. Cell 10, 833-845. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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