Tumor necrosis factor alpha, TNFalpha Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Tumor necrosis factor alpha, TNFalpha |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tumor necrosis factor (TNF, cachexin, or cachectin, and formerly known as tumor necrosis factor-alpha or TNF-alpha) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase reaction. It was originally identified in mouse serum after injection with Mycobacterium bovis strain bacillus Calmette-Guerin (BCG) and endotoxin. TNF is primarily produced as a 212-amino acid-long type II transmembrane protein arranged in stable homotrimers.[1] The human TNF gene maps to chromosome 6p21.3, spans about 3 kilobases and contains 4 exons.[2] The primary role of TNF is in the regulation of immune cells. Dysregulation of TNF production has been implicated in a variety of human diseases, including |
| Immunogen | Immunogen: A synthetic peptide (conjugated to KLH) corresponding to the region of mouse TNFα. |
| Other Names | n/a |
| Gene, Accession # | [TNFalpha] |
| Catalog # | MBS355096 |
| Price | $275 |
| Order / More Info | Tumor necrosis factor alpha, TNFalpha Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kriegler M, Perez C, DeFay K, Albert I, Lu SD (1988). A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF. Cell 53 (1): 45-53. 2. Old LJ (1985). Tumor necrosis factor (TNF). Science 230 (4726): 630-2. 3. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, Lanctot KL (2010). A meta-analysis of cytokines in major depression. Biol Psychiatry 67 (5): 446-457. 4. Brynskov J, Foegh P, Pedersen G, Ellervik C, Kirkegaard T, Bingham A, Saermark T (2002). Tumour necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease. Gut 51 (1): 37-43. |
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