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Antigenic Specificity | EPHA2 (Center) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: monkey) |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This EPHA2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 518-552 amino acids from the Central region of human EPHA2. Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and i |
Immunogen | n/a |
Other Names | [Ephrin type-A receptor 2; Epithelial cell kinase; Tyrosine-protein kinase receptor ECK; EPHA2; ECK] |
Gene, Accession # | [EPHA2], Gene ID: 1969, NCBI: NP_004422.2, UniProt: P29317 |
Catalog # | MBS9215209 |
Price | $165, $370 |
Order / More Info | EPHA2 (Center) Antibody from MYBIOSOURCE INC. |
Product Specific References | Lindberg R.A.,et al.Mol. Cell. Biol. 10:6316-6324(1990). Gregory S.G.,et al.Nature 441:315-321(2006). Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. Miao H.,et al.Nat. Cell Biol. 2:62-69(2000). Zelinski D.P.,et al.Cancer Res. 61:2301-2306(2001). |