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Antigenic Specificity | Endoglin/CD105 (Angiogenesis Marker) |
Clone | [ENG/3269] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b, kappa |
Format | purified |
Size | 0.02 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (With BSA & Azide at 0.2mg/ml), 0.1 mg (Without BSA at 1mg/ml) |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-form |
Immunogen | Immunogen: Recombinant human Endoglin protein fragment (aa74-251) (exact sequence is proprietary) |
Other Names | [CD105; END; Endoglin; Eng; HHT1; S-endoglin] |
Gene, Accession # | [ENG], Gene ID: 2022, NCBI: NP_000109.1, UniProt: P17813 |
Catalog # | MBS4380857 |
Price | $190, $340, $340 |
Order / More Info | Endoglin/CD105 (Angiogenesis Marker) Antibody from MYBIOSOURCE INC. |
Product Specific References | Altomonte, M., et al. 1996. Expression and structural features of Endoglin (CD105), a transforming growth factor 1 and 3 binding protein, in human melanoma. Br. J. Cancer 74: 1586-1591. |