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Antigenic Specificity | MDM2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 (1). Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 (2-4). Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 (3). |
Immunogen | Immunogen: Recombinant protein of human MDM2 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [MDM2; HDMX; MGC5370; MGC71221; hdm2] |
Gene, Accession # | [MDM2], Gene ID: 4193, NCBI: NP_001138811.1, UniProt: Q00987 |
Catalog # | MBS8503113 |
Price | $310 |
Order / More Info | MDM2 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Haupt, Y. et al. (1997) Nature 387, 296-299. 2. Mayo, L.D. and Donner, D.B. (2001) Proc. Natl. Acad. Sci. USA 98, 11598-11603. 3. Zhou, B. P. et al. (2001) Nat. Cell Biol. 3, 973-981. 4. Grossman, S. R. et al. (1998) Mol. Cell 2, 405-415. |