KIR2DS2 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | KIR2DS2 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Western Blot (WB), Immunofluorescence (IF) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: KIR2DS2 antibody is human specific. Multiple isoforms are known to exist. Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells (1). The KIR proteins are classified by the number of extracellular immunoglobulin domains and by whether they have a long (L) or short (S) cytoplasmic domain (2,3). KIR proteins are thought to play an important role in regulation of the immune response (3). KIR2DS2 downregulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells and is a receptor on natural killer (NK) cells for HLA-C alleles (3,4). |
| Immunogen | Immunogen: KIR2DS2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human KIR2DS2. Buffer: Supplied in PBS containing 0.02% sodium azide. Positive Control 1: 293 Cell Lysate |
| Other Names | [Killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 2, KIR2DL3, MHC class I NK cell receptor, Natural killer-associated transcript 5, NKAT5, p58 KIR, p58 natural killer cell receptor clone CL-49, p58 NK receptor], [KIR2DS2; KIR2DS2; NKAT5; cl-49; CD158J; CD158b; NKAT-5; 183ActI; KIR-2DS2; CD158J; NKAT5; NKAT-5; p58 NK receptor CL-49] |
| Gene, Accession # | [KIR2DS2], Gene ID: 100132285, NCBI: NP_036444, UniProt: P43631 |
| Catalog # | MBS154357 |
| Price | $375 |
| Order / More Info | KIR2DS2 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Colonna M and Samaridis J. Cloning of immunoglobulin-superfamily members associated with HLA-C and HLA-B recognition by human natural killer cells. Science 1995; 268:405-8. Biassoni R, Cantoni C, Falco M, et al. The human leukocyte antigen (HLA)-C-specific activatory or inhibitory natural killer cell receptors display highly homologous extracellular domains but differ in their transmembrane and intracytoplasmic portions. J. Exp. Med. 1996; 183:645-50. Wagtmann N, Biassoni R, Cantoni C, et al. Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains. Immunity 1995; 2:439-49. Moesta AK and Parham P. Diverse functionality among human NK cell receptors for the C1 epitope of HLA-C: KIR2DS2, KIR2DL2, and KIR2DL3. Front. Immunol. 2012; 3:336. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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