NIACR1 (Center), 200-228 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | NIACR1 (Center), 200-228 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: mouse) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This NIACR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of human NIACR1. NIACR1 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of ta |
| Immunogen | n/a |
| Other Names | [Hydroxycarboxylic acid receptor 2; G-protein coupled receptor 109A; G-protein coupled receptor HM74A; Niacin receptor 1; Nicotinic acid receptor; HCAR2; GPR109A; HCA2; HM74A; NIACR1] |
| Gene, Accession # | [HCAR2], Gene ID: 338442, NCBI: NP_808219.1, UniProt: Q8TDS4 |
| Catalog # | MBS9214263 |
| Price | $165, $370 |
| Order / More Info | NIACR1 (Center), 200-228 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Li, X., et al. Biochem. Pharmacol. 80(9):1450-1457(2010) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Li, G., et al. J. Biol. Chem. 285(29):22605-22618(2010) Mandrika, I., et al. Biochem. Biophys. Res. Commun. 395(2):281-287(2010) Shen, H.C., et al. J. Med. Chem. 53(6):2666-2670(2010) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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