APH1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | APH1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | APH1 Antibody: APH1 was initially identified as a component of the Notch pathway in C. elegans. Along with nicastrin, PEN2, and presenilin-1 APH1 is an essential component of the gamma-secretase complex which cleave the amyloid precursor protein (APP) at what are known as the gamma- and epsilon-sites and can lead to the accumulation of the Amyloid beta peptide (Abeta) cleavage product that is associated with Alzheimer's disease. APH1 exists in at least three distinct isoforms with APH1a as the principal isoform present in the gamma-secretase complex. Mice deficient in this isoform, but not the other two, were lethal at E10.5, with impaired vascular and neural development observed. |
| Immunogen | Immunogen: APH1 antibody was raised against a 13 amino acid synthetic peptide from near the amino terminus of human APH1a. Buffer: APH1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| Other Names | [APH1; APH-1; APH-1A; CGI-78; 6530402N02Rik; PSF; UNQ579/PRO1141; Gamma-secretase subunit APH-1A; Aph-1alpha; APH-1a; anterior pharynx defective 1 homolog A (C. elegans)], [APH1A; APH1A; APH-1; APH-1A; CGI-78; 6530402N02Rik; PSF; APH-1a] |
| Gene, Accession # | [APH1A], Gene ID: 51107, NCBI: AAH08732, UniProt: Q96BI3 |
| Catalog # | MBS150469 |
| Price | $375 |
| Order / More Info | APH1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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