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Antigenic Specificity | MUL1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: MUL1 antibody detects endogenous levels of total MUL1. Function: Exhibits weak E3 ubiquitin-protein ligase activity (PubMed:18591963, PubMed:19407830, PubMed:22410793). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:18591963, PubMed:19407830, PubMed:22410793). Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting phosphorylated Akt to proteosomal degradation (PubMed:22410793). Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations (PubMed:19407830). Plays a role in |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Mitochondrion Outer Membrane. Peroxisome. Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome. Tissue Specificity: Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus. Predicted Cross Reactivity: Pig, Bovine, Horse, Rabbit, Dog Similarity: Pig (100%), Bovine (85%), Horse (100%), Rabbit (100%), Dog (100%) |
Other Names | [0610009K11Rik; AV000801; C1orf166; Chromosome 1 open reading frame 166; E3 SUMO-protein ligase MUL1; E3 ubiquitin ligase; E3 ubiquitin protein ligase MUL1; E3 ubiquitin-protein ligase MUL1; FLJ12875; GIDE; Growth inhibition and death E3 ligase; MAPL; Mitochondrial anchored protein ligase; mitochondrial E3 ubiquitin ligase 1; mitochondrial E3 ubiquitin protein ligase 1; Mitochondrial ubiquitin ligase activator of NFKB 1; Mitochondrial-anchored protein ligase; MUL1; MUL1_HUMAN; MULAN; Putative NF kappa B activating protein 266; Putative NF-kappa-B-activating protein 266; RGD1309944; RING finger protein 218; RNF218; RP11-401M16.2; RP23-25C1.10-002] |
Gene, Accession # | [MUL1], Gene ID: 79594, NCBI: NP_078820.2, UniProt: Q969V5 |
Catalog # | MBS9604103 |
Price | $240, $280 |
Order / More Info | MUL1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |