NOTCH3 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-NOTCH3 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | NOTCH3 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate (1). Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD) (2). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes (3-4). Notch3 is a member of the Notch family and is p |
| Immunogen | Immunogen: A synthetic peptide of human NOTCH3 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [CASIL; CADASIL] |
| Gene, Accession # | [NOTCH3], Gene ID: 4854, NCBI: NP_000426.2, UniProt: Q9UM47 |
| Catalog # | MBS8502602 |
| Price | $310 |
| Order / More Info | NOTCH3 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Artavanis-Tsakonas, S. et al. (1999) Science 284, 770-6. 2. Chan, Y.M. and Jan, Y.N. (1998) Cell 94, 423-6. 3. Schroeter, E.H. et al. (1998) Nature 393, 382-6. 4. Rand, M.D. et al. (2000) Mol Cell Biol 20, 1825-35. 5. Baron, M. (2003) Semin Cell Dev Biol 14, 113-9. 6. Kalimo, H. et al. (2002) Brain Pathol 12, 371-84. 7. Karlstrom, H. et al. (2002) Proc Natl Acad Sci U S A 99, 17119-24. 8. Monet, M. et al. (2007) Hum Mol Genet 16, 982-92. 9. Park, J.T. et al. (2006) Cancer Res 66, 6312-8. 10. Gramantieri, L. et al. (2007) Liver Int 27, 997-1007. 11. Yamaguchi, N. et al. (2008) Cancer Res 68, 1881-8. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies