Edit |   |
---|---|
Antigenic Specificity | XRCC1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: XRCC1 antibody detects endogenous levels of total XRCC1. Description: XRCC1 Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3).Function: Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.Subunit Structure: Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF. Interacts |
Immunogen | Immunogen: A synthesized peptide derived from human XRCC1 Subcellular Location: Nucleus. Accumulates at sites of DNA damage. Tissue Specificity: Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level). |
Other Names | [DNA repair protein XRCC1; RCC; X ray repair complementing defective repair in chinese hamster; X ray Repair Complementing Defective Repair in Chinese Hamster Cells; X ray repair complementing defective repair in chinese hamster cells 1; X ray repair cross complementing 1; X ray repair cross complementing protein 1; X ray repair, complementing defective, repair in Chinese hamster; X-ray repair cross-complementing protein 1; XRCC 1; Xrcc1; XRCC1_HUMAN] |
Gene, Accession # | [XRCC1], Gene ID: 7515, NCBI: NP_006288.2, UniProt: P18887 |
Catalog # | MBS9600233 |
Price | $240, $280 |
Order / More Info | XRCC1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |