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Antigenic Specificity | MB21D1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.8mg/ml |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total MB21D1 protein. Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2', 5' phosphodiester linkage at the GpA step and the formation of a 3', 5' phosphodiester linkage at the ApG step, producing c[G(2', 5')pA(3', 5')p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred b |
Immunogen | Immunogen: Synthetic peptide corresponding to internal residues of human MB21D1 Immunogen Type: Peptide |
Other Names | [cGAS; h-cGAS; C6orf150] |
Gene, Accession # | [MB21D1], Gene ID: 115004, NCBI: NP_612450, UniProt: Q8N884 |
Catalog # | MBS9429755 |
Price | $255 |
Order / More Info | MB21D1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |