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Antigenic Specificity | Mouse/Human CD44 |
Clone | [IM7] |
Host Species | Rat |
Reactive Species | mouse, human |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation. |
Immunogen | n/a |
Other Names | [Mouse/Human CD44; CD44 antigen; CD44; CDw44; Epican; Phagocytic glycoprotein 1; PGP-1; Phagocytic glycoprotein I; PGP-I; CD44; LHR; MDU2; MDU3; MIC4] |
Gene, Accession # | [CD44], Gene ID: 12505, NCBI: NP_001034240.1, UniProt: P15379 |
Catalog # | MBS2553915 |
Price | $85, $100 |
Order / More Info | Mouse/Human CD44 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Haynes BF, et al. 1991. Cancer Cells 3:347. 3. Goldstein LA, et al. 1989. Cell 56:1063. 4. Mikecz K, et al. 1995. Nat. Med. 1:558. 5. Hegde V, et al. 2008. J. Leukocyte Biol. 84:134. 6. Liu T, et al. 2009. Biol. Direct 4:40. |