Edit |   |
---|---|
Antigenic Specificity | WAS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total WAS protein. Wiskott-Aldrich syndrome proteins (WASPs) mediate actin dynamics by activating the Arp2/3 actin nucleation complex in response to activated Rho family GTPases. In mammals, five WASP family members have been described. Hematopoietic WASP and ubiquitously expressed N-WASP are autoinhibited in unstimulated cells. Upon stimulation they are activated by cdc42, which relieves the autoinhibition in conjunction with phosphatidyl inositol 4,5-bisphosphate. Three WAVE (Wasf, SCAR) family proteins are similar in sequence to WASP and N-WASP but lack the WASP/N-WASP autoinhibition domains and are indirectly activated by Rac (reviewed in 1). Both WASP and WAVE functions appear to be essential, a |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human WAS. |
Other Names | [WAS; IMD2; THC; THC1; WASP] |
Gene, Accession # | [WAS], Gene ID: 7454, NCBI: NP_000368.1, UniProt: P42768 |
Catalog # | MBS9414112 |
Price | $255 |
Order / More Info | WAS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |