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Antigenic Specificity | RBM5 (N-term), 18-46 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: bovine, mouse, rat) |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This RBM5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human RBM5. Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalyti |
Immunogen | n/a |
Other Names | [RNA-binding protein 5; Protein G15; Putative tumor suppressor LUCA15; RNA-binding motif protein 5; Renal carcinoma antigen NY-REN-9; RBM5] |
Gene, Accession # | [RBM5], Gene ID: 10181, NCBI: NP_005769.1, UniProt: P52756 |
Catalog # | MBS9212074 |
Price | $165, $370 |
Order / More Info | RBM5 (N-term), 18-46 Antibody from MYBIOSOURCE INC. |
Product Specific References | Sugliani, M., et al. Plant Cell 22(6):1936-1946(2010) Rintala-Maki, N.D., et al. Gene 445 (1-2), 7-16 (2009) : Kotlajich, M.V., et al. Mol. Cell 32(2):162-164(2008) Fushimi, K., et al. Proc. Natl. Acad. Sci. U.S.A. 105(41):15708-15713(2008) Bonnal, S., et al. Mol. Cell 32(1):81-95(2008) |