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Antigenic Specificity | GAS |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Steroid receptor co-activators (SRCs) were initially described as nuclear receptor transcription co-activators, but they have recently been determined to co-regulate transcription initiated by other transcription factors. GAS is a recently identified glutamate-rich protein that interacts with SRC1, but not GRIP1 or AIB1, the other two members of the SRC family. GAS can also interact with the alpha subunit of the estrogen receptor (ERalpha), but not other receptors such as the retinoic acid receptor a, suggesting the interaction between GAS and ERalpha is relatively specific. Depletion of GAS by RNA interference in MCF7 cells led to a decrease in the mRNA and protein levels of ER target genes such as pS2, c-Myc and cyclin D1, indicating the |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 15 amino acid peptide from near the carboxy terminus of human GAS. |
Other Names | [Glutamate-rich coactivator interacting with SRC1, PTIP-associated 1 protein, PA1] |
Gene, Accession # | [GAS], Gene ID: 79447, NCBI: NP_078792 |
Catalog # | MBS9410151 |
Price | $320 |
Order / More Info | GAS Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |