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Antigenic Specificity | ROR2 (N-term), 19-50 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 1.6 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This ROR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-50 amino acids from the N-terminal region of human ROR2. ROR2 is a tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. This Type I membrane protein is expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues. Defects in ROR2 are a cause of brachydactyly type B1 (BDB1). BDB1 is an autosomal dominant skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In BDB1 the middle phalanges are short |
Immunogen | n/a |
Other Names | [Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase; receptor-related 2; ROR2; NTRKR2] |
Gene, Accession # | [ROR2], Gene ID: 4920, NCBI: NP_004551.2, UniProt: Q01974 |
Catalog # | MBS9202424 |
Price | $165, $370 |
Order / More Info | ROR2 (N-term), 19-50 Antibody from MYBIOSOURCE INC. |
Product Specific References | Afzal, A.R., et al., Nat. Genet. 25(4):419-422 (2000). Oldridge, M., et al., Nat. Genet. 24(3):275-278 (2000). van Bokhoven, H., et al., Nat. Genet. 25(4):423-426 (2000). Schwabe, G.C., et al., Am. J. Hum. Genet. 67(4):822-831 (2000). Masiakowski, P., et al., J. Biol. Chem. 267(36):26181-26190 (1992). |