Phospho-Thr23/25 REDD1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Thr23/25 REDD1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Specific for the ~34k REDD1 phosphorylated at Thr23/25. Immunolabeling is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Affinity purified rabbit polyclonal antibody. REDD1, Regulated in Development and DNA damage responses 1, is induced by hypoxia, cell stress, and apoptosis. Reduced REDD1 levels can sensitize cells towards apoptosis, where elevated levels of REDD1 induced by hypoxia can desensitize cells to apoptotic stimuli (Schwarzer et al, 2005). REDD1 has a crucial role in inhibiting mammalian rapamycin complex 1 (mTORC1) signaling during hypoxic stress (Katiyar et al, 2009). It has been shown that the rapid degradation of REDD1 is mediated by the CUL4A-DDB1-ROC1-b-TRCP E3 lig |
| Immunogen | Antigen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr23/25 of human REDD1. Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr23/25 conjugated to KLH. Immunogen Species: Human |
| Other Names | [DNA damage-inducible transcript 4 protein; DNA damage-inducible transcript 4 protein; DNA damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; protein regulated in development and DNA damage response 1; DNA-damage-inducible transcript 4; HIF-1 responsive protein RTP801; Protein regulated in development and DNA damage response 1], [DDIT4; DDIT4; Dig2; REDD1; REDD-1; REDD1; RTP801; REDD-1] |
| Gene, Accession # | [DDIT4], Gene ID: 54541, NCBI: NP_061931.1, UniProt: Q9NX09 |
| Catalog # | MBS502208 |
| Price | $360 |
| Order / More Info | Phospho-Thr23/25 REDD1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | • Schwarzer r, Tondera D, Arnold W, Giese K, Klippel A, Kaufmann J (2005) REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. Oncogene 24(7): 1138-49.• Katiyar S, Liu E, Knutzen CA, Lang ES, Lombardo CR, Sankar S, Toth JI, Petroski MD, Ronai Z, Chiang GC (2009) REDD1, an inhibitor of mTOR signaling, is regulated by the CUL4A-DDB1 ubiquitin ligase. EMBO Rep 10(8):866-72. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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