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Antigenic Specificity | YES1 |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and indu |
Immunogen | n/a |
Other Names | [Purified Mouse (Mab); Tyrosine-protein kinase Yes; 2.7.10.2; Proto-oncogene c-Yes; p61-Yes; YES1; YES] |
Gene, Accession # | [YES1], Gene ID: 7525, NCBI: NP_005424.1, UniProt: P07947 |
Catalog # | MBS9216879 |
Price | $165, $370 |
Order / More Info | YES1 Antibody from MYBIOSOURCE INC. |
Product Specific References | Sukegawa J.,et al.Mol. Cell. Biol. 7:41-47(1987). Nusbaum C.,et al.Nature 437:551-555(2005). Mural R.J.,et al.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. Sugawara K.,et al.Br. J. Cancer 63:508-513(1991). Krueger J.,et al.Oncogene 6:933-940(1991). |