IL-12 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | IL-12 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat |
| Isotype | n/a |
| Format | Protein G purified |
| Size | 0.1 mg, 0.2 mg |
| Concentration | n/a |
| Applications | Western Blot (WB), IHC (Immunohistochemistry), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | IL12 is secreted by peripheral lymphocytes after induction. It is produced mainly by B-cells and to a lesser extent by T-cells. The most powerful inducers of IL12 are bacteria, bacterial products, and parasites. IL12 is produced after stimulation with Phorbol esters or Calcium ionophore by human B- lymphoblastoid cells. The IL12 receptor,CD212, appears to be a single protein of approximately 110 kDa. Up to 1000-9000 high affinity IL12 receptors/cell are expressed on peripheral blood mononuclear cells activated by various mitogens for T-cells or by IL2. IL12 receptors are present on activated T-cells expressing CD4 and CD8 and on activated CD56 (+) natural killer cells. Resting peripheral blood mononuclear cells, tonsillar B-cells, or tonsil |
| Immunogen | Source Note: Polyclonal Interleukin-12 antibody was produced from sera of rabbits immunized with synthetic protein containing Interleukin-12 C terminal antigenic determinants. |
| Other Names | [Rabbit IL-12 purified; Il12; NKSF2; CLMF; Interleukin-12; il-12;; pab], [IL12B; NKSF2; IL-12B; CLMF p40; NKSF2] |
| Gene, Accession # | [IL-12], Gene ID: 3593, NCBI: NP_002178.2, UniProt: P29460 |
| Catalog # | MBS551053 |
| Price | $375, $495 |
| Order / More Info | IL-12 Antibody from MYBIOSOURCE INC. |
| Product Specific References | • gc1q receptor ligation selectively down-regulates Human IL-12 production through activation of the phosphoinositide 3-kinase pathway.J. Immunol., Oct 2005; 175: 4706 - 4714. • Human IL-12 (p35) gene activation involves selective remodeling of a single nucleosome within a region of the promoter containing critical sp1-binding sites.Blood, Jun 2003; 101: 4894 - 4902. • impaired accumulation and function of memory cd4 t cells in Human IL-12 receptor 1 deficiency.J. Immunol., Jan 2003; 170: 597 - 603. • biosynthesis and posttranslational regulation of Human IL-12.J. Immunol., May 2000; 164: 4752 - 4761. • disparate intracellular processing of Human IL-12 preprotein subunits: atypical processing of the p35 signal peptide.J. Immunol., Jan 2000; 164: 839 - 847. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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