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Antigenic Specificity | Superoxide Dismutase 1 (SOD1) Unfolded Beta Barrel |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunoblot, Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes a conformation-specific epitope where the beta barrel is unfolded. Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme that catalyzes the dismutation of the superoxide radical O2-to oxygen and hydrogen peroxide which are then metabolized to H2O and O2 by catalase and glutathione peroxidase. SODs play an important role in antioxidant defense mechanisms. SOD1 contains Cu and Zn ions and exists as a homodimer in cell cytoplasm. Each SOD1 monomer folds into an eight-stranded Greek key beta-barrel. These strands are connected by seven external loops. Misfolding of SOD1 has been implicated in Amyotrophic Lateral Sclerosis (ALS). |
Immunogen | Immunogen: Synthetic peptide corresponding to unfolded beta barrel (UbetaB) region at the N-terminus of SOD1. |
Other Names | [SOD1; Superoxide dismutase [Cu-Zn]; superoxide dismutase [Cu-Zn]; superoxide dismutase 1; Superoxide dismutase 1; hSod1], [SOD1; SOD1; ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer; hSod1] |
Gene, Accession # | [SOD1], Gene ID: 6647, NCBI: CAG46542, UniProt: P00441 |
Catalog # | MBS191316 |
Price | $405 |
Order / More Info | Superoxide Dismutase 1 (SOD1) Unfolded Beta Barrel Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |