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Antigenic Specificity | Heat Shock Factor 2 |
Clone | monoclonal |
Host Species | Rat |
Reactive Species | human, mouse, rat |
Isotype | IgG1k |
Format | affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes GST-fusion proteins. Heat-shock factors(HSF1-4) play important roles in responding to the cellular stress signals, such as heat, heavy metals, and oxidative reagents and a wide variety of other stressors. HSF1 is activated by stress, whereas HSF2 lacks intrinsic stress responsiveness although the HSF2 expression changes which is coinciding with the functions of HSF2 in development. HSF1 and HSF2 form heterotrimers when bound to satellite III DNA in nuclear stress bodies, subnuclear structures in which HSF1 induces transcription. Upon stress, HSF2 DNA binding is HSF1 dependent. The heterotrimerization of HSF1 and HSF2 integrates transcriptional activation in response to distinct stress and developmental stimuli. |
Immunogen | Antigen Preparation: A recombinant human HSF2 (1-536aa) protein. |
Other Names | [Rat HSF2; Heat shock factor protein 2; Heat Shock Factor 2 (HSF2); Heat shock transcription factor (HSTF2); Rat HSF2], [HSF2; HSF 2; HSTF 2] |
Gene, Accession # | [HSF2], Gene ID: 3298 |
Catalog # | MBS460643 |
Price | $285 |
Order / More Info | Heat Shock Factor 2 Antibody from MYBIOSOURCE INC. |
Product Specific References | Schuetz,T.J., Gallo,G.J., Sheldon,L., Tempst,P. and Kingston,R.E. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. Proc. Natl. Acad. Sci. U.S.A. 88 (16), 6911-6915 (1991). |