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Antigenic Specificity | HSF4 |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: HSF4 antibody detects endogenous levels of total HSF4. Description: Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity.Function: DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.Subunit Structure: Homotrimer. Exhibits constitutive DNA binding and forms trimers even in the absence of stress. Interacts with ALKBH4, DUSP26, MAPK1, MAPK2 and MAP kinase p38.Po |
Immunogen | Immunogen: Purified recombinant fragment of human HSF4 expressed in E. Coli Subcellular Location: Nucleus Tissue Specificity: Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues. |
Other Names | [Cataract, Marner; CTM; Heat shock factor protein 4; Heat shock transcription factor 4; hHSF4; HSF 4; HSF4; HSF4_HUMAN; HSTF 4] |
Gene, Accession # | [HSF4], Gene ID: 3299, NCBI: NP_001035757.1, UniProt: Q9ULV5 |
Catalog # | MBS9602413 |
Price | $235, $295, $370 |
Order / More Info | HSF4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |