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Antigenic Specificity | AXIN1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIP |
Immunogen | Immunogen: Recombinant Human Axin-1 protein (418-707AA) |
Other Names | [Axin-1; Axis inhibition protein 1; hAxin; AXIN1; AXIN] |
Gene, Accession # | [AXIN1], Gene ID: 8312, NCBI: NP_003493.1, UniProt: O15169 |
Catalog # | MBS7050007 |
Price | $160, $235 |
Order / More Info | AXIN1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |