Ep-CAM Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Ep-CAM |
| Clone | [G8.8] |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytometry (FC), Immunocytochemistry (IHC), Immunohistochemistry (IHC) (frozen), Immunoprecipitation (IP), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The G8.8 antibody reacts with CD326/Ep-CAM (Epithelial Cell Adhesion Molecule), also known as gp-40 in the Mouse. Ep-CAM is a 40-42-kDa cell-surface glycoprotein expressed on thymic epithelial cells, thymic dendritic cells, immature thymocytes, a small subset of peripheral T lymphocytes, intestinal epithelium, kidney-collecting tubule epithelium, keRatinocytes, Langerhans cells, as well as lymph node and splenic dendrititc cells. Ep-CAM is a 40 kD glycoprotein and can be detected at the basolateral membrane of the majority of epithelial tissues, where it is intriCately linked with the cadherin-Catenin complex and hence the fundamental WNT pathway responsible for intracellular signalling and polarity. This antigen functions as a homotypic ca |
| Immunogen | Source Note: G8.8 is a Rat monoclonal IgG2a antibody derived by fusion of spleen lymphocytes from Rats repeatedly immunized with a glycoconjugates isloted from TE-71 BALB/c Mouse derived medullary thymic epithelial cells and Rat X63-Ag8.653 myeloma cells. |
| Other Names | [Epithelial cell adhesion molecule; Epithelial cell adhesion molecule; epithelial cell adhesion molecule; OTTHUMP00000159073; OTTHUMP00000200307; OTTHUMP00000200426; epithelial glycoprotein 314; human epithelial glycoprotein-2; cell surface glycoprotein Trop-1; adenocarcinoma-associated antigen; tumor-associated calcium signal transducer 1; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); epithelial cell adhesion molecule; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; Epithelial cell surface antigen; Epithelial glycoprotein; EGP; Epithelial glycoprotein 314; EGP314; hEGP314; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1], [EPCAM; EPCAM; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; GA733-2; TACSTD1; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1] |
| Gene, Accession # | Gene ID: 4072, UniProt: P16422 |
| Catalog # | MBS570187 |
| Price | $415 |
| Order / More Info | Ep-CAM Antibody from MYBIOSOURCE INC. |
| Product Specific References | Farr, A., Nelson, A., Truex, J. And Hosier, S. (1991). Epithelial heterogeneity in the murine thymus: a cell surface glycoprotein expressed by subcapsular and medullary epithelium. The Journal of Histochemistry and Cytochemistry 39, 645-53. Lee, M., Sharrow, S., Farr, A., Singer, A. and Udey M. (1994). Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells. Journal of Immunology Mol 152, 5653-59. Borkowski, T., Nelson, A., Farr, A. and Udey, M. (1996). Expression of gp40, the murine homologue of Human epithelial cell adhesion molecule (Ep-Cam), by murine dendritic cells. Eur. J. Immunol. 26, 110-14. Nelson, A., Dunn, R., Peach, R., Aruffo, A. and Farr, A. (1996). The murine homolog of Human Ep-CAM, a homotypic adhesion molecule, is expressed by thymocytes and thymic epithelial cells. Eur. J. Immunol. 26, 401-408. Went, P., Vasei, M., Bubendorf, L., Terracciano, L., Tornillo, L., Riede, U., Kononen, J., Simon, R., Sauter, G. And Baeuerle, P.A. (2006). Frequent high-level expression of the immunotherapeutic target Ep-CAM in colon, stomach, prostate and lung cancers bladder. British Journal of Cancer 94, 128-135. Maaser, K. and Borlak, J. (2008). A genom-wide expression analysis identifies a network of EpCAM-induced cel cycle regulators. British Journal of Cancer 99, 1635-43 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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