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Antigenic Specificity | RASSF1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this |
Immunogen | Immunogen: Recombinant Human Ras association domain-containing protein 1 protein (23-145AA) |
Other Names | [Ras association domain-containing protein 1; RASSF1] |
Gene, Accession # | [RASSF1], Gene ID: 11186, NCBI: NP_001193886.1, UniProt: Q9NS23 |
Catalog # | MBS7104693 |
Price | $160, $235 |
Order / More Info | RASSF1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |