Phospho-EGFR-Y998 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Phospho-EGFR-Y998 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The epidermal growth factor (EGF) receptor is a transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Ligand binding results in receptor dimerization, autophosphorylation, activation of downstream signaling, internalization, and lysosomal degradation (1, 2). Phosphorylation of EGF receptor (EGFR) at Tyr845 in the kinase domain is implicated in stabilizing the activation loop, maintaining the active state enzyme, and providing a binding surface for substrate proteins (3, 4). c-Src is involved in phosphorylation of EGFR at Tyr845 (5). The SH2 domain of PLC gamma binds at phospho-Tyr992, resulting in activation of PLC gamma-mediated downstream signaling (6). Phosphorylation of EGFR at Tyr1045 creates a major docking site f |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding Y998 of human EGFR Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [ERBB; HER1; mENA; ERBB1; PIG61; EGFR] |
| Gene, Accession # | [EGFR], Gene ID: 1956, NCBI: NP_005219.2, UniProt: P00533 |
| Catalog # | MBS8527419 |
| Price | $310 |
| Order / More Info | Phospho-EGFR-Y998 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Hackel, P.O. et al. (1999) CurrOpin Cell Biol 11, 184-9. 2. Zwick, E. et al. (1999) Trends PharmacolSci 20, 408-12. 3. Cooper, J.A. and Howell, B. (1993) Cell 73, 1051-4. 4. Hubbard, S.R. et al. (1994) Nature 372, 746-54. 5. Biscardi, J.S. et al. (1999) J BiolChem 274, 8335-43. 6. Emlet, D.R. et al. (1997) J BiolChem 272, 4079-86. 7. Levkowitz, G. et al. (1999) Mol Cell 4, 1029-40. 8. Ettenberg, S.A. et al. (1999) Oncogene 18, 1855-66. 9. Rojas, M. et al. (1996) J BiolChem 271, 27456-61. 10. Feinmesser, R.L. et al. (1999) J BiolChem 274, 16168-73. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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