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Antigenic Specificity | RANBP3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. |
Immunogen | Immunogen: Recombinant human Ran-binding protein 3 protein (N-250AA) |
Other Names | [Ran-binding protein 3; RanBP3; RANBP3] |
Gene, Accession # | [RANBP3], Gene ID: 8498, NCBI: NP_001287794.1, UniProt: Q9H6Z4 |
Catalog # | MBS7044287 |
Price | $120, $160 |
Order / More Info | RANBP3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |