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Antigenic Specificity | Human Ubiquitin-like protein ISG15 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | biotin conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Ubiquitin-like protein that is conjugated to intracellular target proteins after IFN-alpha or IFN-beta stimulation. Its enzymatic pathway is partially distinct from that of ubiquitin, differing in substrate specificity and interaction with ligating enzymes. ISG15 conjugation pathway uses a dedicated E1 enzyme, but seems to converge with the Ub conjugation pathway at the level of a specific E2 enzyme. Targets include STAT1, SERPINA3G/SPI2A, JAK1, MAPK3/ERK1, PLCG1, EIF2AK2/PKR, MX1/MxA, and RIG-1. Deconjugated by USP18/UBP43. Shows specific chemotactic activity towards neutrophils and activates them to induce release of eosinophil chemotactic factors. May serve as a trans-acting binding factor directing the association of ligated target prot |
Immunogen | Immunogen: Recombinant human Ubiquitin-like protein ISG15 protein Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-50366 / sc-130791 |
Other Names | [G1P2; UCRP; Interferon-induced 15 kDa protein Interferon-induced 17 kDa protein IP17 Ubiquitin cross-reactive protein hUCRP], [ISG15; ISG15; G1P2; IP17; UCRP; IFI15; IMD38; hUCRP; G1P2; UCRP; IP17; hUCRP] |
Gene, Accession # | [ISG15], Gene ID: 9636, NCBI: NP_005092.1, UniProt: P05161 |
Catalog # | MBS715615 |
Price | $160, $235 |
Order / More Info | Human Ubiquitin-like protein ISG15 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |