Edit |   |
---|---|
Antigenic Specificity | c-erbB-2/Her2 |
Clone | [ABM45F5] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2b kappa |
Format | Protein G purified |
Size | 0.025 mg, 0.1 mg |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | HER2, a known proto-oncogene, is located at the long arm of human chromosome 17 (17q12), encoding a type 1 tyrosine kinase growth factor receptor and the role of HER2 in the development of numerous types of human cancer. HER2 is a transmembrane receptor comprising an extracellular domain (ECD), a single transmembrane domain, and an intracellular domain (ICD) with tyrosine-kinase activity. The high-expression and amplification of C-erbB-2 and its protein products (P185) are found in a wide variety of tumors. HER2 is overexpressed in 10% to 35% of gastric and gastroesophageal junction (GEJ) adenocarcinomas. |
Immunogen | Immunogen Information: A partial length protein (amino acids 301-522) was used as the immunogen for this antibody (from extra cellular domain of c-erbB-2). |
Other Names | [ERBB2; HER2; MLN19; NEU; NGL; Metastatic lymph node gene 19 protein; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; to c-erbB-2/Her2; c-erbB-2/Her2; c-erbB-2/Her2], [ERBB2; ERBB2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; HER2; MLN19; NEU; NGL; MLN 19] |
Gene, Accession # | [ERBB2], Gene ID: 2064, NCBI: P04626.1, UniProt: P04626 |
Catalog # | MBS668309 |
Price | $145, $290 |
Order / More Info | c-erbB-2/Her2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |