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Antigenic Specificity | FBXW7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:17434132). Identified substrates include cyclin-E (CCNE1 or CCNE2), JUN, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and |
Immunogen | Immunogen: Recombinant Human F-box/WD repeat-containing protein 7 protein (1-707AA) Conjugation: Non-conjugated |
Other Names | [F-box/WD repeat-containing protein 7; Archipelago homolog; FBXW7] |
Gene, Accession # | [FBXW7], Gene ID: 55294, NCBI: NP_001013433.1, UniProt: Q969H0 |
Catalog # | MBS7053017 |
Price | $160, $235 |
Order / More Info | FBXW7 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |