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Antigenic Specificity | MAGA2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: MAGA2 antibody detects endogenous levels of total MAGA2. Function: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in mela |
Immunogen | Immunogen: A synthesized peptide derived from human MAGA2 Subcellular Location: Nucleus Tissue Specificity: Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. |
Other Names | [Cancer/testis antigen 1.2; Cancer/testis antigen family 1, member 2; CT1.2; MAGE 2; MAGE 2 antigen; MAGE2; MAGEA 2; MAGEA2; MAGEA2A; MAGEA2B; Melanoma antigen 2; Melanoma antigen family A, 2; Melanoma antigen family A, 2B; Melanoma antigen, family A, 2, copy b; Melanoma associated antigen 2] |
Gene, Accession # | [MAGA2], Gene ID: 4101, NCBI: NP_001269430.1, UniProt: P43356 |
Catalog # | MBS9602888 |
Price | $240, $280 |
Order / More Info | MAGA2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |