Edit |   |
---|---|
Antigenic Specificity | HP1 alpha |
Clone | monoclonal |
Host Species | Mouse |
Reactive Species | human; mouse; rat |
Isotype | IgG1 |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemmistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: HP1 alpha Monoclonal Antibody detects endogenous levels of total HP1 alpha. Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. |
Immunogen | Immunogen: Purified recombinant fragment of human HP1 alpha expressed in E. Coli. Fragment: Fab fragment |
Other Names | [CBX5; Antigen p25; CBX5; CBX5_HUMAN; CG8409; Chromobox 5; Chromobox homolog 5 (HP1 alpha homolog, Drosophila); Chromobox homolog 5; Chromobox protein homolog 5; Epididymis luminal protein 25; HEL25; Heterochromatin protein 1 alpha; Heterochromatin protein 1; Heterochromatin protein 1 homolog alpha; HP1 alpha; HP1 alpha homolog; HP1; HP1A; HP1Hs alpha; Su(var)205;] |
Gene, Accession # | [HP1 alpha], Gene ID: 23468, NCBI: NP_001120793.1, UniProt: P45973 |
Catalog # | MBS9611256 |
Price | $235, $295, $370 |
Order / More Info | HP1 alpha Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |