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Antigenic Specificity | Phospho-AKT1 (T450) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human (predicted reactivity: bovine, mouse, rat) |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Dot Blot (DB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This AKT1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T450 of human AKT1. The serine-threonine protein kinase encoded by the AKT1gene is catalytically inactive in serum-starved primary andimmortalized fibroblasts. AKT1 and the related AKT2 are activatedby platelet-derived growth factor. The activation is rapid andspecific, and it is abrogated by mutations in the pleckstrinhomology domain of AKT1. It was shown that the activation occursthrough phosphatidylinositol 3-kinase. In the developing nervoussystem AKT is a critical mediator of growth factor-induced neuronalsurvival. Survival factors can suppress apoptosis i |
Immunogen | n/a |
Other Names | [RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; Proto-oncogene c-Akt; RAC-PK-alpha; AKT1; PKB; RAC] |
Gene, Accession # | [AKT1], Gene ID: 207, NCBI: NP_001014431.1, UniProt: P31749 |
Catalog # | MBS9204216 |
Price | $165, $370 |
Order / More Info | Phospho-AKT1 (T450) Antibody from MYBIOSOURCE INC. |
Product Specific References | Zhao, W.D., et al. Infect. Immun. 78(11):4809-4816(2010) Sanematsu, F., et al. Circ. Res. 107(9):1102-1105(2010) Nicodemus, K.K., et al. Arch. Gen. Psychiatry 67(10):991-1001(2010) Treekitkarnmongkol, W., et al. World J. Gastroenterol. 16(32):4047-4054(2010) Chen, J., et al. PLoS ONE 5 (8), E12293 (2010) : |