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Antigenic Specificity | Tumor Endothelial Marker 5 (TEM5) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | n/a |
Isotype | n/a |
Format | unconjugated |
Size | 0.05 mg |
Concentration | n/a |
Applications | Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Tumor Endothelial Marker 5 [Rabbit polyclonal antibody recognizes human Tumor Endothelial Marker 5]. This antibody recognizes an epitope within the extracellular domain of human TEM5. Tumor endothelial marker 5 (TEM5) is a member of the adhesion family of GPCRs and is upregulated in endothelial cells during tumor and physiologic angiogenesis. Soluble TEM5 (sTEM5) is shed by endothelial cells during angiogenesis and binds to glycosaminoglycans on extracellular matrix and cell surface proteoglycans. After proteolytic processing, an RGD-binding site for integrin alpha v beta 3 is exposed on sTEM5. Adhesion of endothelial cells to immobilized proteolytically processed sTEM5 promotes their survival. |
Immunogen | Antigen: Synthetic peptide conjugated to KLH |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS194439 |
Price | $520 |
Order / More Info | Tumor Endothelial Marker 5 (TEM5) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |