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Antigenic Specificity | p53 (S376) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein A purified |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 349-385 amino acids from human. Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the funct |
Immunogen | n/a |
Other Names | [Purified Rabbit (Pab); Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53; TP53; P53] |
Gene, Accession # | [p53], Gene ID: 7157, NCBI: NP_000537.3, UniProt: P04637 |
Catalog # | MBS9231235 |
Price | $165, $370 |
Order / More Info | p53 (S376) Antibody from MYBIOSOURCE INC. |
Product Specific References | Zakut-Houri R.,et al.EMBO J. 4:1251-1255(1985). Lamb P.,et al.Mol. Cell. Biol. 6:1379-1385(1986). Harlow E.,et al.Mol. Cell. Biol. 5:1601-1610(1985). Harris N.,et al.Mol. Cell. Biol. 6:4650-4656(1986). Buchman V.L.,et al.Gene 70:245-252(1988). |