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Antigenic Specificity | Pellino 1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Pellino 1 Antibody: The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways that lead to activation of MAP kinases and transcription factors. Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4-IRAK-TRAF6 complex, ultimately resulting in the activation of NF-κB. Like other members of the Pellino family, Pellino 1 is an E3 ubiquitin ligase, able to catalyze the polyubiquitination of IRAK1. It is activated via phosphorylation by either IRAK1 and IRAK4 or the IKK-related kinases IKK-ε and TBK1. In addition to phosphorylation, Pellino 1 activity is also modulated via ubiquitination and sumoylation. |
Immunogen | Immunogen: Rabbit polyclonal Pellino 1 antibody was raised against a 15 amino acid peptide near the carboxy terminus of human Pellino 1. Buffer: Pellino 1 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [Pellino 1; PRISM; E3 ubiquitin-protein ligase pellino homolog 1; Pellino-related intracellular-signaling molecule; Pellino-1; pellino E3 ubiquitin protein ligase 1], [PELI1; PELI1; PRISM; Pellino-1] |
Gene, Accession # | [PELI1], Gene ID: 57162, NCBI: NP_065702, UniProt: Q96FA3 |
Catalog # | MBS153500 |
Price | $375 |
Order / More Info | Pellino 1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |