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Antigenic Specificity | CaMK4 (Phospho-Thr196/200) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of CaMK4 only when phosphorylated at threonine196/threonine 200. Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Oury F, et al. (2010)Genes Dev 24, 2330-42. Di |
Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of threonine 200 (M-K-T(p)-V-C) derived from Human CaMK4 or threonine 196 (M-K-T(p)-V-C) derived from Mouse CaMK4. |
Other Names | [CAM kinase-GR; CAMK4; CaMK IV; Calspermin; KCC4] |
Gene, Accession # | [CaMK4], Gene ID: 814, NCBI: NP_001735.1, UniProt: Q16566 |
Catalog # | MBS9405208 |
Price | $200, $255 |
Order / More Info | CaMK4 (Phospho-Thr196/200) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |