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Antigenic Specificity | Cardif (Human) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Immunocytochemistry (ICC), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Recognizes human cardif. Detects a band of ~65kDa by Western blot. RIG-I (retinoic acid-inducible gene I; Ddx58) and Mda5 (melanoma differentiation-associated gene 5, also known as Ifih1 or Helicard) are proteins that sense viral replication intermediates, such as double-stranded RNA and triggers the host antiviral programs. These molecules signal the downstream activation of NF-kappaB and IFN regulatory factor (IRF) -3, which coordinately regulate the expression of type-I interferons. Cardif (also called VISA/IPS-1/MAVS) is a CARD (caspase activation and recruitment domain)-containing adaptor protein that interacts with the CARD domain of RIG-I and Mda5, leading to the activation of NF-kappaB and IRF3. Cardif is located to the mitochondria |
Immunogen | Immunogen: Recombinant human Cardif (CARD adapter inducing interferon- beta ) (aa 160-450). |
Other Names | [CARD adapter inducing interferon- beta; IPS-1; Interferon- beta promoter stimulator protein 1; MAVS; Mitochondrial antiviral signalling protein; VISA; Virus-induced signalling adapter], [MAVS; MAVS; IPS1; VISA; IPS-1; CARDIF; IPS1; KIAA1271; VISA; MAVS; Cardif; IPS-1; VISA] |
Gene, Accession # | Gene ID: 57506, NCBI: Q7Z434.2, UniProt: Q7Z434 |
Catalog # | MBS565363 |
Price | $500 |
Order / More Info | Cardif (Human) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |