Human CD49d/VLA-4 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human CD49d/VLA-4 |
| Clone | polyclonal |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 100 tests |
| Concentration | n/a |
| Applications | n/a |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Human CD49d; Mr 150kDa. CD49d, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin ?4 chain. CD49d associates noncovalently with CD29, the integrin ?1 subunit, to form the ?4?1 very late antigen-4 (VLA-4) heterodimer. Integrin ?4 can also associate with integrin ?7 to form the ?4?7 heterodimer. It is expressed on most leukocytes with the possible exception of neutrophils. VLA-4 mediates leukocyte binding to CD106 (VCAM-1) and is involved in the migration of leukocytes from blood to tissue at sites of inflammation. VLA-4 can also provide a costimulatory signal to T cells for activation and proliferation. The ?4?7 integrin heterodimer is expressed on a small subpopulation of thymoc |
| Immunogen | n/a |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS670394 |
| Price | $240 |
| Order / More Info | Human CD49d/VLA-4 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Barclay, A.N., M.H. Brown, S.K.A. Law, A.J. McKnight, M.G. Tomlinson, and P.A. van der Merwe, eds. 1997. The Leukocyte Antigens Facts Book, 2nd Edition, CD49d Section, Academic Press, New York, p. 262. 2. Lobb, R.R., and M.E. Hemler. 1994. J. Clin. Invest. 94:1722. 3. Alon, R., P.D. Kassner, M.W. Carr, E.B. Finger, M.E. Hemler, and T.A. Springer. 1995. J. Cell. Biol. 128:1243. 4. Berlin, C.,R.F. Bargatze, J.J. Campbell, U.H. von Andrian, M.C. Szabo, S.R. Hasslen, R.D. Nelson, E.L. Berg, S.L. Erlandsen, and E.C. Butcher. 1995. Cell 80:413. 5. Leitinger, B., et al., 2002, J. Cell. Sci. 115:963-72. PMID: 11870215 6. McDowall, A., et al., 2003, J Clin Invest. 111 (1):51-60. PMID: 12511588 |
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