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Antigenic Specificity | Human Receptor-interacting serine/threonine-protein kinase 3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production. |
Immunogen | Immunogen: Recombinant human Receptor-interacting serine/threonine-protein kinase 3 protein (1-120aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47368 / sc-135171 |
Other Names | [RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3; RIPK3; RIP3], [RIPK3; RIPK3; RIP3; RIP3; RIP-3] |
Gene, Accession # | [RIPK3], Gene ID: 11035, NCBI: NP_006862.2, UniProt: Q9Y572 |
Catalog # | MBS1494303 |
Price | $120, $160 |
Order / More Info | Human Receptor-interacting serine/threonine-protein kinase 3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |